The Effect of Aerobic Training with Vitamin C Supplementation on Myeloperoxidase, Asymmetric Dimethyl Arginine and Blood Pressure in Middle-Age Hypertensive Overweight Men

 Ailin Alishahi 1 , Kamal Azizbeigi 1 , * , Khalid Mohammadzadeh Salamat 1 , Mozafar Yektayar 1

۱ Department of Physical Education and Sport Science, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran
* Corresponding Author: Ph.D. in Exercise Physiology, Department of Physical Education and Sport Science, Sanandaj Branch, Islamic Azad University, Sanandaj,

Abstract

Background: Cardiovascular diseases such as hypertension are global health concerns.

Objectives: The purpose of this study was the effect of intensive aerobic training with vitamin C supplementation on myeloperoxidase (MPO), asymmetric dimethyl arginine (ADMA), and blood pressure (BP) in hypertensive men.

Methods: Forty hypertensive men (age: 44.6 ± ۳٫۵ y, body mass index: 28.2 ± ۱٫۲ kg.m-2) volunteered to participate in this study and were randomly divided into four groups of aerobic training with vitamin C (ATV; N = 10), aerobic training with placebo (ATP; N = 10), vitamin C group (VC; N = 10) and control (Con; N = 10). The exercise training consisted of running training, which was done three times a week for 10 weeks, with the intensity of 75% – 85% HR max, and the duration of 20 – 45 minutes. ATP and VC groups consumed daily 500 mg of vitamin C or placebo. Fasting blood samples were measured before the start training protocol and 24 hour after last training sessions to measure MPO and ADMA in the serum.

Results: The results of present study showed that ADMA and BP were significantly decreased only in ATV and ATP (P ≤ ۰٫۰۵). However, MPO did not change significantly (P > 0.05). Also, were seen that no significant difference between ATV and ATP groups (P > 0.05).

Conclusions: It can be concluded that, aerobic training caused to decrease of dimethyl arginine, that can be a good strategy for control or decrease of blood pressure in hypertensive subjects, however intensive aerobic training with vitamin C may have better efficacy.
Keywords
Oxidative Stress, Aerobic Training, Hypertension