Effect of Exercise Training and Aging on Klotho Signaling in the Heart

Effect of Exercise Training and Aging on Klotho Signaling in the Heart

Journal of Clinical Research in Paramedical Sciences

Behrouz Baghaiee 1 , * , Maliheh Barzegari 2 , Mohammad Hossein Sadeghi Zali 3 , Mehdi Hakimi 4

۱ Department of Physical Education and Sport Science, Jolfa Branch, Islamic Azad University, Jolfa, Iran

۲ Deparment of Nutrition in the Community, Tabriz University of Medical Science, Tabriz, Iran

۳ Department of Microbiology, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran

۴ Department of Physical Education and Sport Science, Marivan Branch, Islamic Azad University, Marivan, Iran

Abstract

Aging, if accompanied by a sedentary lifestyle, can result in different diseases including cardiovascular diseases. Klotho, a protein found in the kidneys and other tissues of the body, is influenced by age and level of physical activity. In this paper, using 66 papers published in PubMed and SID between 1997 and 2018, we examined the mechanism of action of Klotho on cardiac hypertrophy under senescence conditions. Studies have shown that aging results in the development of oxidative stress as well as increased MAPK and TRPC6. These factors push the heart towards pathological hypertrophy, where deficiency of Klotho accelerates this trend. Nevertheless, exercise training causes enhanced Klotho levels. This protein is able to inhibit oxidative stress as an upstream factor in the activity of MAPK and TRPC6.
Keywords

Aging, Klotho, Exercise Training

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